Divorced from his wife Kris in 1991, Kardashian married two more times. He and his third wife Ellen Pierson tied the knot in 2003, shortly after Kardashian was diagnosed with esophageal cancer. Kardashian died only weeks later on September 30, 2003, at his Los Angeles home. He was 59 years old.

Robert Kardashian's Will stated that “all intangible property and tangible property” would be distributed to a trust for his children's benefit. The Will went on to provide one exception, that Robert Kardashian's then wife, Ellen, would be given the Indian Wells real property and its “furnishings”.

Kardashian was married to Kris Jenner from 1978 until they divorced in 1991. Then he was married to Jan Ashley from 1998 until they divorced in 1999. Then he was married to Ellen Pearson from 2003 until his death two months later. Kardashian was diagnosed with esophageal cancer in July 2003.

Caitlyn's connection to Simpson is part of the Kardashian/Simpson web. Robert Kardashian Sr., the first husband of Caitlyn's ex-wife Kris Jenner, was Simpson's best friend and eventual lawyer during his double murder trial in 1994.