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Learn to pronounce sub·stance

/ˈsəbstəns/
noun
  1. a particular kind of matter with uniform properties.
    "a steel tube coated with a waxy substance"
    synonyms: material, matter, stuff, medium, fabric
  2. the real physical matter of which a person or thing consists and which has a tangible, solid presence.
    "proteins compose much of the actual substance of the body"
    synonyms: solidity, body, corporeality, reality, actuality, materiality, concreteness, tangibility, density, mass, weight, shape, structure
  3. the quality of being important, valid, or significant.
    "he had yet to accomplish anything of substance"
  4. the essential nature underlying phenomena, which is subject to changes and accidents.

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substance from www.samhsa.gov
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Substance may refer to: Matter, anything that has mass and takes up space. Contents. 1 Chemistry; 2 Arts, entertainment, and media.
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noun. that of which a thing consists; physical matter or material: form and substance. a species of matter of definite chemical composition: a chalky substance.
substance from www.collinsdictionary.com
Substance is the quality of being important or significant. ... It's questionable whether anything of substance has been achieved. Synonyms: importance, ...